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KMID : 0939920190510031249
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대한암학회지
2019 Volume.51 No. 3 p.1249 ~ p.1256
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Prospective Validation of The Korean Cancer Study Group Geriatric Score (KG)-7, a Novel Geriatric Screening Tool, in Older Patients with Advanced Cancer Undergoing First-line Palliative Chemotherapy
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Kim Jin-Won
Kim Se-Hyun
Lee Yun-Gyoo
Hwang In-Gyu
Kim Jin-Young
Koh Su-Jin
Ko Yoon-Ho
Shin Seong-Hoon
Woo In-Sook
Hong Soo-Jong
Kim Tae-Yong
Baek Ji-Yeon
Kim Hyun-Jung
Kim Hyo-Jung
Lee Myung-Ah
Kwon Jung-Hye
Hong Yong-Sang
Ryoo Hun-Mo
Lee Kyung-Hee
Kim Jee-Hyun
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Abstract
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Purpose: The purpose of this study was to prospectively validate the Korean Cancer Study Group Geriatric Score (KG)-7, a novel geriatric screening tool, in older patients with advanced cancer planned to undergo first-line palliative chemotherapy.
Materials and Methods: Participants answered the KG-7 questionnaire before undergoing geriatric assessment (GA) and first-line palliative chemotherapy. The performance of KG-7 was evaluated by calculating the sensitivity (SE), specificity (SP), positive and negative predictive value (PPV and NPV), balanced accuracy (BA), and area under the curve (AUC).
Results: The baseline GA and KG-7 results were collected from 301 patients. The median age was 75 years (range, 70 to 93 years). Abnormal GA was documented in 222 patients (73.8%). Based on the ≤ 5 cut-off value of KG-7 for abnormal GA, abnormal KG-7 score was shown in 200 patients (66.4%). KG-7 showed SE, SP, PPV, NPV, and BA of 75.7%, 59.7%, 84.4%, 46.0%, and 67.7%, respectively; AUC was 0.745 (95% confidence interval, 0.687 to 0.803). Furthermore, patients with higher KG-7 scores showed significantly longer survival (p=0.006).
Conclusion: KG-7 appears to be adequate in identifying patients with abnormal GA prospectively. Hence, KG-7 can be a useful screening tool for Asian countries with limited resources and high patient volume.
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KEYWORD
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Geriatric assessment, KG-7, Screening tools, Prospective, Validation
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